common ancestor to the Sal1,2,3, Bcl11A, B and Znf342 genes

The mammalian Sal, Bcl, and ZNF342 family of genes share a conserved common N-terminal ~12 amino acids that is found in the short first coding exon and is in each case is followed by a C2HC zinc finger in the second exon, and which together has been demonstrated in the case of Sal1 to bind HDAC proteins and mediate (in part) the repression of that protein (Kiefer etal 2002).

the genomic structure of this region of the gene is generally conserved between mammals and fish in so far as has been examined.

links to genomic blast output generally showing the exon structure within human, mouse, rat, fugu, and zebrafish.

neighbor joining tree from clustalw aligned Nterm sequence from Bcl11A, B, znf342, and Sal1,2,3,4

link to jalview display of alignment.

Nterm , clustalw

Bcl11a

Bcl11b

znf342

sal1

sal2

sal3

sal4 (reported in Camp etal 2003, but no sequence reported), I am assuming this is the sal1 homolog that is on the human X chromosome.