Philip William Tucker
Academic Positions:
Morrow
Centennial Professor, Institute for Cellular & Molecular Biology,
University of Texas, Austin, Texas 78712-1095, 1995 to Present.
Professor,
Department of Microbiology, University of Texas Southwestern Medical School,
Dallas, Texas 75235, 1986-1994.
Associate
Professor, Department of Microbiology, University of Texas Southwestern Medical
School, Dallas, Texas 75235, 1980-1985.
Assistant
Professor, Department of Biochemistry, University of Mississippi Medical
Center, Jackson, Mississippi, 1979-1980.
Postdoctoral
Fellow, Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin
(Drs. Fred Blattner and Oliver. Smithies), 1977-1979.
Postdoctoral
Fellow, MRC Laboratory of Molecular Biology, Cambridge, England, (Dr. Max.
Perutz), l975-1977.
Postdoctoral
Fellow, Roche Institute of Molecular Biology, Nutley, New Jersey, (Dr. Sidney
Pestka), 1974-1975.
Graduate Research
Student (Ph.D.), Department of Chemistry, Massachusetts Institute of Technology
(Dr. Al Cotton), 1969-1972; Moved with mentor to complete thesis at Texas A
& M University, College Station, Texas, 1972-1974.
Undergraduate
Research Student (BS), Dept. of Chemistry, Clayton Foundation, University of
Texas at Austin, Austin, Texas (Dr. Barry Kitto), 1967-1968.
Honors
and Affiliations:
National
Science Merit Award, 1964
First
Annual Dabney Memorial Chemistry Fellowship, 1972
NSF-Nato
Postdoctoral Fellowship, 1975
Viral-Oncology
Training Fellowship, 1977
NIH
Public Health Fellowship, 1978
American
Chemical Society, Phi Lambda Upsilon, Phi Sigma, AAI
NIH
Merit Award 1992
Visiting
Professorships: Tsinghua University,
1993; LSU Medical Center, 1996; University of Iowa, 1998; University of Texas
at Dallas, 2001.
Editorial Boards (past or
present): Journal of
Immunology, Nucleic Acids Research, Gene, Immunologic Research, International
Immunology, Molecular and Cellular Biology, Genes and Development, Molecular and Cellular Biology.
Administrative/Review
Boards (past or present):
Allergy and Immunochemistry NIH Study Section; Damon Runyon Postdoctoral
Program, American Cancer Society; NCI Leukemia, Lymphoma and Myeloma Progress
Review Group; Consultant: Hybritech Inc., GenPharm International, AbGenix;
Advisory board: Sagres Discovery, Seattle Genetics, Oklahoma Medical Research
Foundation; Founding Scientist and Scientific Advisory Board, Gene Screen.
1. Tucker, P.W., Shubert, H. and Jeffries,
L.L. (1967). Effect of Stimulus Rise
Time on the Latency and Amplitude of the Auditory Evoked Response. EEG Clin. Neurophysiol. 63 Suppl. A: 401.
2. Swanson, A.A., Jetter, J., and
Tucker, P.W. (1968). Inorganic Cations in the Crystalline Lens from Young and
Aged Rats. J. Geront. 23: 502-505.
3. Swanson, A.A., Jetter, J. and Tucker, P.W. (1969). Microsomal Enzymes in the Porcine Lens. Rep.
Biol. Med. 26: 595-601.
4. Swanson, A.A., Jeter, J. and Tucker,
P.W. (1970). Opthalmic Vehicles. II. Comparison of Ointment and Polyvinyl
Alcohol 1.4%. Ophtholmologica 160:
265-270.
5. Culp, T.W., Creger, C.R., Swanson,
A.A., Tucker, P.W. and Couch, J.R. (1969).
Lipid Synthesis in Ocular Tissue.
Exptl. Eye Res. 7: 134-146.
6. Culp, T.W., Tucker, P.W., Jeter, J. and
Deiterman, L.H. (1970). In vivo Synthesis of Lipids in Rabbit
Cornea, Iris and Lens. Exp.
Eye Res. 9: 98-105.
7. Tucker, P.W., Culp, T.W., Ratliff, C.R.
and Hall, F.D. (1971). Chromatographic
Analysis of Ocular Lipids and Lipoproteins.
I. Bovine and Human Iris. Biochem.
Biophys. Acta 218: 259-268.
8. Tucker, P.W. and George, W. (1972).
Microfibers Within Fibers. Polymer Sci. 12: 364-368.
9. Cotton, F.A., Hazen, E.E., Jr. and
Tucker, P.W. (1974). Selective
Chemical Modification of Arginine
Residues of Staphylococcal
Nuclease in the Presence and Absence of
Active Site Specific Ligands. J. Am. Chem. Soc. 95: 2367.
10. Tucker, P.W. (1974). Chemical and
Crystallographic Studies of the Staphylococcal
Nuclease. Ph.D. Thesis, Massachusetts Institute of Technology.
11. Cotton, F.A., Gillen, R.G., Gohil, R.N. Hazen, E.E., Jr., Kizchner, C.R., Nagyvary, J., Stanislowski, A.G. and Tucker, P.W. (1975).
The Tumor Inhibiting Properties of the Neutral P-O-ethyl Ester of
Adenosine-3': 5'- monophosphate in Correlation
with its Crystal and Molecular
Structure. Proc. Natl. Acad. Sci. 72:
1335-1339.
12. Collins, D.M., Cotton, F.A. Hazen E.E.,
Legg, M.J. and Tucker, P.W. (1975). The Nucleotide Binding Site of the
Staphylococcal Nuclease. In: Structure
and Conformation of Nucleic
Acids and Protein-Nucleic Acid Interactions. M. Sundralingam and S.T. Rao (eds.) University Park Press Baltimore,
p. 317.
13. Pestka,
S., Green, M., McInnes, J. and Tucker, P. (1975). Isolation, Purification and
Cell-free Translation of Immunoglobulin
Messenger RNAs from Immunoglobulin Producing Cells and Variants.
In: Immune RNA in Neoplasm.
M.A. Fink (ed.), Academic Press,
New York., p. 121-141.
14. Cotton, F.A., Hazen, E.E., Jr., and Tucker,
P.W. (1976). Existence of two
Cationic-Binding Forms of Staphylococcal Nuclease Suggesting a Conformational Change Induced by Low
pH. Arch.
Biochem. Biophys. 172: 74-79.
15. Brandsch, R., Graves, P., Jilka, R.,
Okuyama, A. and Tucker, P.W. (1976).
Isolation, Characterization, and Translation of Immunoglobulin
Messenger RNAs. Fed. Proc. 35: 1359 (Abstract).
16. Tucker, P. and Pestka, S. (1977). De Novo Synthesis and Glycosylation of the
MOPC-46B Mouse Immunoglobulin Light Chain in Cell-Free Extracts. J.
Biol. Chem. 252: 4474-4486.
17. Tucker, P. and Pestka, S. (1977).
Glycosylation of a Specific Acceptor Protein Synthesied De Novo in a Cell-free
Extract. Biochemical Society Transactions 4: 1246-1250.
18. Tucker, P.W., and Perutz, M.F.
(1977). Mechanism of Charge
Compensation and Impairment of Cooperative Functions in Haemoglobin Tacoma (Arg
B12(30) β"Ser). J.
Mol. Biol. 114: 415-420.
19. Tucker,
P.W.,Hazen,E.E.,Jr.andCotton,F.A.(1978). Staphylococcal
Nuclease Reviewed: A Prototypic Study in
Contemporary Enzymology. I. Isolation and Physical and Enzymatic
Properties. Mol. Cell. Biochem. 22:
67-77.
20. Tucker, P.W., Phillips, S.V., Caughey, W.
and Perutz, M.F. (1978). Structure of Deoxyhaemoglobin Sydney (Val Ell(67)β"Ala) and
Carbonmonoxyhaemoglobin Zurich (His E7(63)β"Arg) and
the Role of the Two Distal Residues in Ligand Binding. Proc.
Natl. Acad. Sci. U.S.A. 75:
1076-1080.
21. Tucker, P.W. and Perutz, M.F.
(1978). The Function of the Distal
Residues in Ligand Binding in Haemoglobin. In: The Red Cell 21: pp.
3-15. G.J. Brewer, ed. Academic Press, New York.
22. Tucker, P.W. and Perutz, M.F. (1978). Three-Dimensional Structure of
Abnormal Haemoglobins. In: Clinical and
Biochemical Aspects of Haemoglobin Abnormalities 7: pp.1-15. W. Caughey and
J. Hercules, eds. Academic Press, New York.
23. Blattner, F.R., Blechl, A.E.,
Denniston-Thompson, K., Faber, H.,
Richards, J.E., Slightom, J.L., Tucker, P.W. and Smithies, O. (1978). Cloning of Fetal Gamma Globin and Mouse
Alpha-Type Globin DNA: I. Preparation and Screening of Shotgun
Collections. Science 202: 1279-1284.
24. Smithies, O., Blechl, A.E.,
Denniston-Thompson, K., Newell, N., Richards, J.E., Slightom, J.L., Tucker,
P.W. and Blattner, F.R., (1978).
Cloning of Fetal Gamma Globin and Mouse Alpha-Type Globin DNA: II. Characterization and Partial Sequencing.
Science 202: 1284-1289.
25. Tucker, P.W., Hazen, E.E., Jr., and
Cotton, F.A. (1979). Staphylococcal
Nuclease Reviewed: A Prototypic Study
in Contemporary Enzymology. II.
Solution Studies of the Nucleotide Binding Site. Mol. Cell. Biochem. 23: 3-16.
26. Tucker, P.W., Hazen, E.E., Jr. and
Cotton, F.A. (1979). Staphylococcal Nuclease Reviewed: A
Prototypic Study in Contemporary Enzymology
III. Correlation of the Three-Dimensional Structure with the Mechanism
of Enzymatic Action and Polypeptide Chain Folding. Mol. Cell. Biochem. 23: 67-86.
27. Tucker, P.W., Hazen, E.E. and
Cotton,F.A.(1979). Staphylococcal
Nuclease Reviewed: A Prototypic Study in Contemporary Enzymology. IV. The Nuclease as a Model for Protein
Folding. Mol. Cell. Biochem. 23:
131-141.
28. Tucker, P.W., Marcu, K.N., Slightom, J.L.
and Blattner, F.R. (1979). Structure of
the Constant and 3' Untranslated Regions of the Murine Gamma 2b Heavy Chain
mRNA. Science 206: 1299-1303.
29. Tucker, P.W., Marcu, K.N., Newell, N.,
Richards, J.E. and Blattner, F.R.
(1979). Sequence of the Cloned Gene of
the Constant Region of Murine Gamma 2b Immunoglobulin Heavy (1980). Science
206: 1303-1306.
30. Smithies, O., Slightom, J.S.,
Tucker, P.W. (1979). Genomic Clones
from Unfractionated DNA. In: From Gene to Protein:Information Transfer in Normal and Abnormal Cells.
T.R. Russell, K. Brew, H. Faber, and J. Schultz, eds. Academic Press, pp. 167-186.
31. Vanin, E.F., Goldberg, G.L., Tucker, P.W.
and Smithies, O. (1980). A Mouse Globin-related Pseudo Gene (ψα 30.5) Lacking
Intervening Sequences. Nature
286: 222-226.
32. Newell, N., Richards, J.E., Tucker, P.W.
and Blattner, F.R. (1980). J Genes for
Immunoglobulin Heavy Chains in Mouse.
Science 209:
1128-1132.
33. Robinson, R.A., P.W. Tucker, and D.J.
O'Callahan. (1980). Mapping and
Molecular Cloning of Host Genomic and Herpes Virus Oncogenic DNA
Sequences. Proc. Fifth International Herpesvirus Workshop, Cold Spring Harbor
Laboratory Symposium, Cold Spring Harbor, p. 120.
34. Tucker, P.W., Liu, C.-P., Mushinski, J.F., and Blattner, F.R. (1980).
Mapping of the Heavy Chain Genes for Mouse IgM and IgD.
Science 209:
1348-1353.
35. Tucker,
P.W., Liu, C.-P., Mushinski, J. F., and Blattner, F.R. (1980). Mouse
Immunoglobulin D: mRNA and Genomic DNA Sequences. Science 209:
1353-1360.
36. Blattner, F.R., Keifer, D.O., Moore,
D.D., DeWet, J., Williams, B.G., and Tucker, P.W. (1980). Restriction Maps and Application for EK2
Certification of a Host-Vector System for DNA cloning. Suppl. IX, Vol. II, No.
2 Recombinant
DNA Technical Bulletin pp. 163-167.
37. Mushinski, J.F., Blattner,F.R.,
Owens,J.D., Finkelman,F.D., Kessler, S.W., Fitzmaurice, L., Potter, M., and
Tucker, P.W. (1981). Mouse
Immunoglobulin D: Construction and Characterization of a Cloned δ Chain cDNA. Proc.
Natl. Acad. Sci. U.S.A. 77:
7405-7409.
38. Tucker, P.W., Cheng, H.-L., Mushinski,
J.F., Fitzmaurice, Liu, C.-P. and Blattner,
F.R. (1981). The Molecular
Mechanism of μ and δ Chain Expression: Gene Mapping and Fine Structural Studies. In: B
Lymphocytes in the Immune Response: Functional, Developmental, and Interactive
Properties. Klinman, N., Mosier, D.E., Sher, I. and Vitetta, E.S., (eds),
Elsevier/North Holland, Vol. 15, pp. 34-53.
39. Knapp, M., Strober, S., Liu, C.-P., Tucker,
P.W., Newell, N.and Blattner, F.R. (1981).
Dual Expression of IgM and IgD by a Cloned B Cell Line (BCL1): A Single Copy of the V Gene Is Shared By Two
Adjacent CH Genes. In: B
Lymphocytes in the Immune Response:
Functional, Developmental, and Interactive Properties. Klinman, N.,
Mosier, D.E., Scher, I., and Vitetta, E.S., (eds), Elsevier/North Holland, Vol.
15, pp. 19-30.
40. Fitzmaurice, L., Owens. J., Cheng,
H.-L., Liu, C.-P, Shen, A.L., Blattner, F.R., Tucker, P.W., and Mushinski, J.F.
(1981). Transcription of δ Chain Genes in Mouse Myeloma
Cells and Normal Spleen. In: Immunoglobulin
Idiotypes and Their Expression.
Janeway, C., and Sercarz, E. (eds)., Academic Press, New York, pp.
263-265.
41. Robinson, R.A., O'Callaghan, D.J.,
Davenhayer, S.A., and Tucker, P.W. (1981).
Molecular Cloning of Equine Herpes Virus Type I DNA: Analysis of
Standard and Defective Viral Genomes and Viral Sequences In Oncogenically
Transformed Cells. Proc. Natl. Acad. Sci. U.S.A. 78:
6684-6688.
42. Tucker, P.W., Slightom, J.L., and Blattner,
F.R. (1981). Mouse IgA Heavy Chain Gene Sequence: Implications for Evolution of Immunoglobulin Hinge Exons. Proc. Natl. Acad. Sci. U.S.A. 78:
7684-7688.
43. Knapp, M., Strober, S., Liu, C.-P.,
Tucker, P.W. and Blattner, F.R. (1982).
Simultaneous Expression of Cμ and Cδ
Genes In a Cloned B Cell Line. Proc. Natl. Acad. Sci. U.S.A. 79: 2996-3000.
44. Sims, J., Rabbitts, T., Estess, P.,
Slaughter, C., Tucker, P.W., and Capra, J.D. (1982). Somatic Mutation in Genes
for the variable Portion of the Immunoglobulin Heavy Chain. Science 216: 309-311.
45. Cheng, H.-L, Blattner, F.R., Fitzmaurice,
L., Mushinski, J.F. and Tucker, P.W. (1982). Structure of Membrane and Secreted
Exons for Murine IgD. Nature
296: 410-415.
46. Fitzmaurice, L., Owens, J.,
Blattner, F.R., Cheng, H-L., Tucker, P.W., and Mushinski, J.F. (1982). Mouse
Spleen and IgD Secreting Plasmacytomas Contain Multiple IgD δ Chain RNAs Including More than
one Form of Membrane δ RNA. Nature 296: 459-462.
47. Blattner, F.R., Richards, J. E.,
Shen, A., Knapp, M., Strober, S., Gilliam, A.C., Jones, S., Cheng, H.-L.,
Mushinski, J.F. and Tucker, P.W. (1982). Genetic Aspects of IgD
Expression: I. Analysis of the Cμ-Cδ Complex in Committed and Uncommitted DNA. Ann.
New York Acad. Sci. 399: 1-14.
48. Mushinski, J.F., Thiele, C.J.,
Owens, J.D., Blattner, F.R., Tucker,
P.W. and Fitzmaurice, L. (1982). Genetic Aspects of IgD Expression: II.
Multiple Forms of δ Chain mRNA in
Normal Spleen, Mouse B Cell Lymphomas and Mouse and Human Myelomas. Ann. New York Acad Sci. 399:
15-25.
49. Tucker, P.W., Cheng, H.-L., Richards,
J.E., Fitzmaurice, L.,Mushinski, J.F. and Blattner, F.R. (1982). Genetic
Aspects of IgD Expression: III.
Functional Implications of the Sequence and Organization of the δ Gene. Ann. New York Acad. Sci.
399: 26-40.
50. Yuan, D. and Tucker, P.W. (1982). Effect
of LPS Stimulation on the Transcription and Translation of mRNA for Cell
Surface IgM. J. Exp. Med. 156:
962-974.
51. Estess, P., Otani, F., Milner, E.C.B.,
Capra, J.D., and Tucker, P.W. (1982). Heavy Chain Gene Rearrangements in
Anti-Arsonate Hybridomas. J. Immunol. 129: 2319-2322.
52. Capra, J.D., Slaughter, C., Milner,
E.C.B., Estess, P., and Tucker,
P.W. (1982). Sereological and Structural Analysis of A/J Anti-Arsonate Hybridomas (Review). Immunol. Today 3:
332-335.
53. Word, C.J., Mushinski, J.F., and Tucker,
P.W. (1983). The Murine Immunoglobulin
α Gene
Expresses Multiple Transcripts from a Unique Membrane Exon. EMBO
J. 2: 887-898.
54. Richards, J.E., Gilliam, A.,
Blattner, F.R. and Tucker, P.W. (1983).
Unusual Sequence features in the Murine μ-δ Heavy Chain Region. Nature 306: 483-487.
55. Jones, S., Chen, Y.-W., Isakson, P.,
Layton, J., Pure, E., Word, C.,
Krammer, P.H., Tucker, P.W. and Vitetta, E.S. (1983). Effect of T Cell-derived Lymphokines Containing B Cell
Differentiation Factor(s) for IgG (BCDFγ) on
c-specific mRNA in Murine B cells. J. Immunol. 131: 3049-3051.
56. Yuan, D. and Tucker, P.W. (1983).
Regulation of IgM and IgD Synthesis in
B Lymphocytes I. Changes in
Biosynthesis of Messenger RNA for μ and δ chains. J. Immunol. 132:
1561-1566.
57. Yuan, D. and Tucker. P.W. (1983).
Regulation of IgM and IgD Synthesis in
B lymphocytes II. Translational and
Post-Translational Events. J. Immunol. 132: 1566-1571.
58. Vitetta, E.S., Brooks, K., Chen, Y.-W.,
Isakson, P., Jones, S., Layton, J.,
Mishra, G.C., Pure, E., Weiss, E., Word, C.,
Yuan, D., Tucker, P., Uhr, J.W., and Krammer, P.H. (1984). T Cell-Derived Lymphokines Inducing IgM
and IgG Secretion in Activated Murine B
Cells. Immunol. Rev. 78:
137-157.
59. Blattner, F.R. and Tucker, P.W.
(1984). The Molecular Biology of IgD
(Review). Nature 307:
417-422.
60. Gilliam, A.C., Shen, A., Richards, J.E.,
Blattner, F.R., Mushinski, J.F. and
Tucker, P.W. (1984). Illegitimate Recombination Generates a Class Switch from Cμ to Cδ in an IgD-Secreting Plasmacytoma. Proc.
Natl. Acad. Sci. U.S.A. 81:
4164-4168.
61. Yuan, D. and Tucker, P.W. (1984).
Transcriptional Regulation of the μ-δ Heavy Chain Locus In Normal Murine B Lymphocytes. J.
Exp. Med. 160: 564-583.
62. Brooks, K.H., Kuziel, W.A., Tucker, P.W.,
Uhr, J.W., and Vitetta, E.S. (1984). Cloned Neoplastic B Cells Release a Growth
Factor Which Augments Lymphokine-Mediated Proliferation of Normal B Cells. Curr.
Top. Microb. Immunol. 113: 69-71.
63. Jones, S.L., Layton, J.E., Krammer, P.,
Vitetta, E.S., and Tucker, P.W. (1984). Induction of Isotype-Specific
Immunoglobulin mRNAs by Mitogens and T Cell-Derived Lymphokines. Curr. Top. in Microbiol. 18:
497-510.
64. Wels, J.A., Word, C.J., Rimm, D.,
Der-Balan, G.P., Martinez, H.M., and
Tucker, P.W., and Blattner, F.R. (1985).
Structural Analysis of the
Murine IgG3 Constant Region Gene. EMBO J. 3: 2041-2046.
65. Tucker, P.W. (1986). Construction and
Screening of Recombinant DNA Libraries in Bacteriophage Lambda. In: Handbook of Experimental Immunology. Genetics and Molecular Immunology. Weir, D.M. Ed. Blackwell Sci. Publications,
Edinburgh England. Vol. 3, Chapter 86. pp. 1-16.
66. White, M.B., Word, C.J., Shen, A.L.,
Tucker, P.W. and Blattner, F.R. (1985).
Human Immunoglobulin D: Genomic Sequence of the δ Heavy Chain. Science.
228: 733-737.
67. Yuan, D., Gilliam, A.C., and Tucker, P.W.
(1985). IgM and IgD Expression in Murine B Cells is
Controlled at Multiple Stages (solicited review). Fed. Proc. 44: 2652-2659.
68. McGuire, K., Duncan, W.R. and
Tucker, P.W. (1985). Syrian Hamster DNA Shows Limited Polymorphism at Class
I-like Loci. Immunogenet. 22:
257-268.
69. Tucker, P.W. (1985). Immunoglobulins:
Gene and Protein Structure (solicited
review) Fed. Proc. 44:
2650-2652.
70. Tucker, P.W. (1985). Transcriptional Regulation of IgM and
IgD. Immunol. Today. 6:
181-183.
71. Jones, S., Layton, J., Krammer, P.H.,
Vitetta, E.S., and Tucker, P.W. (1985).
The Effect of T Cell-Derived Lymphokines on the Levels of
Isotype-Specific RNA in Normal B Cells.
J. Mol. Cell. Immunol. 2: 143-153.
72. Tucker, P.W., Edge, M.D., Jones, G.H.,
and Moffatt, J.G. (1995). Synthesis and binding of Dinucleoside Phosphonates in
the Active Site of the Metallo-Enzyme, Staphylococcal Nuclease: Synthetic,
Solution and Preliminary Crystallographic Studies. Inorganica Chemica Acta. 229: 425-436.
73. Kuziel, W.A., Brooks, K.H., Uhr, J.W., Vitetta, E.S., and Tucker, P.W.
(1986). Normal and Neoplastic B
Lymphocytes from the Mouse Synthesize Pro-Opiomelanocartin-Related Messenger
RNA. Science, in press.
74. McGuire, K., Duncan, W.R. and
Tucker, P.W. (1986). Linkage and Sequence of a Class I Gene in the Syrian
Hamster. J. Immunol. 137:
366-372.
75. McGuire, K., Duncan, W. R. and
Tucker, P.W. (1985). Phylogenetic
Conservation of Immunoglobulin Heavy Chains:
Direct Comparison of Hamster and Mouse Cl genes. Nucleic Acids Res. 13: 5611-5628.
76. Gilliam, A.C., Fell, H.P. Carayannopoulos, L. and Tucker, P.W. (1989).
Reciprocal Product of a t(12;15) in Murine Plasmacytoma TEPC 1033: 5' c-myc to
IgH Enhancer Region Transcription in a Mouse Plasmacytoma. Nuc.
Acids. Res. 17: 7533.
77. Fell, H.P., Smith, G. and Tucker, P.W.
(1986). Molecular Analysis of a Novel t(2;14) Translocation in Cases of
Childhood CLL. Science. 232:
491-494.
78. Milner, C.B., Meek, K.D., Rathbun, G.,
Tucker, P.W. and Capra, J.D. (1986). Are Anti-Arsonate Antibody N-Segments
Selected at both the Protein and at the DNA Level? Immunology Today. 7: 36-40.
79. Chen, Y.-W., Word, C.J., Jones, S., Uhr,
J.W., Tucker, P.W. and Vitetta, E.S.
(1986). Double Isotype Production By a Neoplastic B Cell Line: I. Cellular and
Biochemical Characterization of a Variant of BCL1 that Expresses and
Secretes Both IgM and IgG1. J. Exp. Med. 164: 548-561.
80. Chen, Y.-W., Word, C.J., Dev, V., Uhr,
J.W., Vitetta, E.S. and Tucker, P.W. (1986). Double Isotype Production By
a Neoplastic B Cell Line: II.
Allelically Excluded Production of μ and γ1 Heavy Chains Without CH
Gene Rearrangement. J.
Exp. Med. 164: 562-579.
81. Rathbun, G.A. and Tucker, P.W.
(1986). Conservation of Sequences
Necessary for V Gene Recombination (Solicited Review). In: Evolution of the
Immune Response. G. Kelsoe and D.
Shultz. Eds. Academic Press, pp.
85-115.
82. Landolfi,
N.F., Capra, J.D. and Tucker, P.W. (1986).
Germline Sequence of the DH Segment Employed in Ars-A Antibodies: Implications for the Generation
of Junctional Diversity. J. Immunol. 137: 362-365.
83. Rathbun, G., Landolfi, N.F., Tucker,
P.W. and Capra, J.D. (1986). The Germline VH and DH Gene
Segments Encoding the Ars-A Family of Anti-Arsonate Antibodies. In: Proc. Internat. Idiotype Meeting. M.
Reichlin and J.D. Capra, eds. Academic Press, N.Y., pp. 17-30.
84. Weiss, E.A., Tucker, P.W. and Yuan, D.C. (1987). The Cμ Gene is
Transcribed in IgG Bearing B Lymphocytes. J. Mol. Cell. Immunol. 3: 69-81.
85. Noelle, R.J., Kuziel, W.A., Maliszewski,
C.R., McAdams, E. and Tucker, P.W. (1986). Regulation of the Expression of
Multiple Class II Genes in Murine B Cells by B Cell Stimulatory Factor-1. J. Immunol. 137: 1718-1723.
86. Oliver, K., Krammer, P.H., Tucker, P.W.
and Vitetta, E.S.(1987). The Effect of Cytokines and Adherent Cells on the
Interleukin 4-Mediated Induction of Ia Antigens on Resting B Cells By B Cell
Stimulatory Factor-1 (BSF-1)1.
Cell. Immunol. 106: 428-436.
87. Tutt, M.M., Kuziel, W.A., Hackett, J.,
Bennett, M., Tucker, P.W. and Kumar,
V. (1986). Murine Natural Killer (NK) Cells Do Not Express Functional
Transcripts of the α, β, or γ-chain Genes of the T-Cell
Receptor. J. Immunol. 137:
2998- 3001.
88. Born, W., Rathbun, G., Tucker, P.W.,
Marrack, P. and Kappler, J. (1986).
Synchronized Rearrangement of T Cell γ and β Chain Genes
in Fetal Thymocyte Development. Science. 234: 479-482.
89. Landolfi, N.F., Capra, J.D. and
Tucker, P.W. (1986). Interaction of Cell-Type-Specific Nuclear Proteins with
Immunoglobulin VH Promoter-Region Sequences. Nature.
323: 548-551.
90. Galli, G., Guise, J., McDevitt, M.A. and
Tucker, P.W. (1987). Relative Poly(A)
Site Strength and Transcription
Termination Are Critical to Membrane vs.
Secreted μ Chain Expression During B Cell Development. Genes and Development. 1: 471-481.
91. Guise, J., Lim, P., Yuan, D. and Tucker,
P.W. (1988). Alternative Expression of
Secreted and Membrane Forms of Immunoglobulin μ Chain is Regulated by Transcriptional Termination in Stable
Plasmacytoma Transfectants1. J.
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92. Rathbun, G., Capra, J. D. and Tucker, P.W. (1987). Organization of the Murine
Immunoglobulin VH Complex in the
Inbred Strains. EMBO J. 6: 2931-2937.
93. Kuziel, W.A., Takashima, A.,
Bergstresser, P.R., Tigelaar, R.E. and
Tucker, P.W. (1987). Regulation of T
Cell Receptor γ RNA Expression in Murine Thy-1+
Dendritic Epidermal Cells. Nature. 328: 263-266.
94. Fell, H.P. and Tucker, P.W. (1989). Immunoglobulin Genes in Human Immunogenetics: Basic Principles and
Clinical Relevance; S. Litwin, ed., Dekker Inc, N.Y.; Chapter 10, pp. 181-202.
95. Tutt, M.M., Schuler, W., Kuziel, W. A.,
Tucker, P.W., Bennett, M., Bosma, M.J.
and Kumar, V. (1987). T Cell Receptor Genes Do Not Rearrange Or Express
Functional Transcripts in Natural
Killer Cells of Scid Mice. J.
Immunol. 138: 2338-2344.
96. Landolfi, N.F., Capra, J.D. and
Tucker, P.W. (1987).
Protein-Nucleotide Contacts in Immunoglobulin Heavy-Chain
Variable-Region Promoter Regions. Proc. Natl. Acad. Sci. 84: 3851-3855.
97. Rathbun, G., Born, W., Kuziel, W.A.
and Tucker, P.W. (1988). Diversity of the Mouse T Cell Receptor Cγ1 Gene: Structural Analysis in
C57BL/Ka. Immunogenetics 27: 121-126.
98. Allison, J.P., Harran, W. L., Asarnow,
D., Tigelaar, R. E., Bonyhardi, M. and
Tucker, P.W. (1988). γδ Receptors of
Thy- 1+ Dendritic Epidermal
Cells: Implications for Thymic
Differentiation. Immunologic Res., 7: 292-303.
99. Jones, S.L., Riley, S.C., Teale, J.M.,
Ogata, R.T., Klinman, N.R. and Tucker, P.W. (1990). Molecular Analysis of Neonatal IgA Expression: Implications for Class Switching and Somatic
Mutation. Immunologic Res., 9:
147-156.
100. Rathbun, G.A., Otani, F., Milner,
E.C.B., Sanz, I., Capra, J.D. and Tucker, P.W. (1988). Molecular Characterization of the A/J J558 Family
of Heavy Chain Variable Region Gene
Segments. J. Mol. Biol. 202:
383-395.
101. Kuziel, W.A., Tucker, P.W. (1987). Determination of Vector: Insert Junctions in λgt10 cDNAs That Do Not Recut with
Eco RI. Nucleotide Sequence of the λimm434 Hind III-Eco RI DNA Fragment Encoding Part of the cI
Protein. Nuc. Acids Res. 15: 3181.
102. Shen, A., Humphries, C., Tucker, P. and
Blattner, F. (1987). A New Family of
Human Heavy Chain Variable Regions Nonrandomly Rearranged in Familial Chronic
Lymphocytic Leukemia. Proc. Natl. Acad. Sci. U.S.A. 84: 8563-8567.
103. Galli, G., Guise, J. W., Tucker, P.W. and
Nevins, J.R. (1988). Poly A Site Choice
Rather Than Splice Site Choice Governs
the Regulated Production of IgM Heavy Chain RNAs. Proc. Natl. Acad. Sci.
U.S.A. 85: 2439-2443.
104. Hanke, J.H., Landolfi, N.F., Tucker, P.W.
and Capra, J.D. (1988). Identification of Murine Nuclear Proteins
that Bind to the Conserved Octamer Sequence of the Immunoglobulin Promoter
Region. Proc. Natl. Acad. Sci. USA. 85:
3560-3564.
105. Humphries, C.G., Shen, A., Kuziel,
W.A., Capra, J.D., Blattner, F.R. and Tucker, P.W. (1988). A New Human
Immunoglobulin VH Family Preferentially Rearranged in Immature
B-cell Tumors. Nature 331:
446-449.
106. Bonyhadi,
M., Weiss, A., Tucker, P.W., Tigelaar, R.E.
and Allison, J.P. (1987). Delta is the Cx-gene Product in
the γ/δ Antigen
Receptor of Dendritic Epidermal Cells. Nature
330: 574-576.
107. Rathbun, G., Sanz, I., Meek, K.,
Tucker, P.W. and Capra, J.D. (1988). The Molecular Genetics of the Arsonate Idiotypic System of A/J
Mice (Review). Advances in Immunol. F.J. Dixon, ed. Academic Press, NY. vol. 42
pp95-158.
108. Landolfi, N.F., Yin, X.-M., Capra,
J.D., Tucker, P.W. (1988). A Conserved
Heptamer Upstream of the IgH Promoter Region Octamer Can Be the Site of a
Coordinate Protein-DNA Interaction. Nucleic Acids Research, 16: 5503-5515.
109. Guise, J., Galli G., Nevins J. R. and Tucker P.W. (1989). Developmental Regulation of Secreted and
Membrane Forms of Immunoglobulin μ Chain. Immunoglobulin Genes (T.
Honjo, F. Alt and T. Rabbitts, eds).
Academic Press, N.Y. 275-303.
110. Nixon-Fulton, J. L., Kuziel, W. A.,
Santerse, B., Bergstresser, P.R., Tucker, P.W. and Tigelaar, R.E. (1988). Thy-1
Epidermal Cells in Nude Mice are Distinct From Their Counterparts in
Thymus-Bearing Mice. A Study of Morphology,Function and T Cell Receptor mRNA
Expression. J. Immunol., 141:
1897-1903.
111. Ward, R.E., Ward, M.M., Webb, C.F., Altman,
D., Lim, P.L.,Tucker, P.W. and Kohler, H. (1988). Regulation of an Idiotype B Cell Lymphoma: Effects of Antigen and
Anti-Idiotopic Antibodies on Proliferation and Ig Secretion. J.
Immunol., 141: 340-346.
112. Cerny, J., Smith, J.S., Webb, C. and Tucker, P.W. (1988). Properties of Anti-Idiotypic T Cell Lines
Propagated With Syngeneic B
Lymphokines. I. T Cells Bind Intact Idiotypes and Discriminate Between the Somatic
Idiotypic Variants in a Manner Similar
to Anti-Idiotopic Antibodies. J. Immunol., 141: 3718-3725.
113. Landolfi, N.F., Yin, X.-M, Capra, J.D. and Tucker, P.W.
(1989). Protection Analysis (or
"Footprinting") of Specific Protein-DNA Complexes in Crude Nuclear
Extracts Using Methidiumprophyl-EDTA-iron (II). Biotechniques., 7: 500-503.
114. Cambier, J.C., Lehmann, K.L., Tucker,
P.W., Webb, C.F.,Pickles, H.A. and Chien, M.M. (1988). Interactive Aspects of
Transmembrane Signal Transduction By mIg and Fc Receptors on Murine B
Lymphocytes. In: B Cell Development
(UCLA Symposium Proceedings) O. Witte, N. Klinman, M. Howerd, eds. pp 283-292.
115. Sanz, I., Hwang, L.-Y., Hasemann, C.,
Thomas, J., Wasserman, R., Tucker, P.W. and Capra, J.D. (1988). Polymorphisms
of Immunologically Revelant Loci in Human Disease: Autoimmunity and Human Heavy
Chain Variable Regions. Proc. Natl. Acad. Sci. U.S.A., 85: 133-142.
116. Brownell, E., Fell, H.P., Tucker,
P.W., Geurts Van Kessel,A.H.M., Hagemeijer, A. and Rice, N.R. (1988). Regional
Localization of the Human C-Rel Locus Using Translocation Chromosome
Analysis. Oncogene, 2: 527-529.
117. Webb, C.F., Das, C., Coffman, R.L. and
Tucker, P.W. (1989). Induction of
Immunoglobulin μ mRNA in a B
Cell Transfectant Stimulated With
Interleukin-5 and a T-Dependent Antigen.
J. Immunol., 143: 3934-3939.
118. Weiss, E.A., Tucker, P.W., Finkelman, F.D.
and Yuan, D. (1991). Analysis of Immunoglobulin Heavy Chain δ Transcription Termination in the
Production of δs or δm mRNA. J. Immunol., 28:
687-695.
119. Hedley, M.L., Tucker. P. W. and Forman, J.
(1988). Mutation of the Splice Acceptor Sites at the 5' End
of Exon 2 of H-2Kd and H-2Dd Result in the Expression of
Altered Class I Antigens Expressed on the Membrane of L Cells. In Major
Histocompatibility Complex: Genes, Molecules, Function. C. David, Ed. Plenon Press. N.Y. pp. 226-236.
120. Blankenstein, T., Rathbun, G.A.,
Tucker, P.W. and Krawinkel, U.
(1989). Recombination between VH-Pseudogenes. Mol.
Immunol. 26: 319-322.
121. Hedley,
M.L., Forman, J. and Tucker, P.W. (1990). D2d, A D-End Class I Gene.
Tissue Expression and Alternative Processing of the Pre-mRNA. International
Immunol., 2: 25-32.
122. Webb,
C.F., Nakai, C. and Tucker, P.W.
(1991). Immunoglobulin Receptor Signaling Depends on the Carboxyl Terminus but
not the Heavy Chain Class. Proc. Natl. Acad. Sci. U.S.A. 86: 1977-1981.
123. Asarnow,
D. M., Kuziel, W. A., Bonyhadi, M., Tigelaar, R.E., Tucker, P.W., and Allison,
J.P. (1988). Limited Diversity of γδ Antigen
Receptor Genes of Thy-1+ Dendritic Epidermal Cells.
Cell, 55: 837-847.
124. Hedley,
M.L., Drake, B.L., Head, J.R., Tucker,
P.W., and Forman, J. (1989). Differential Expression of the Class I MHC Genes in the Embryo and Placenta During Midgestational
Development in the Mouse. J. Immunol., 142: 4046-4053.
125. Hedley,
M.L., Hunt III, S.W., Brorson, K.A., Andris, J.S., Hood, L., Forman, J. and Tucker, P.W. (1989). Analysis of D2d:
A D-Region Class I Gene. Immunogenetics, 29: 359-365.
126. Drake,
B.L., Hedley, M.L., Head, J.R., Forman,
J. and Tucker, P.W. (1989). Differential Expression of the Class I Major
Histocompatibility Complex Genes in the Developing Mouse Placenta. Trophoblast
Research, 8: 153-169.
127. Schreiber,
K.L., Webb, C., Tucker, P.W., Riblet,
R. and Forman, J. (1989). Developmental Coupling of Expression of the
IgH-linked Minor Antigen H-40 to Membrane Immunoglobulin Expression. Transplantation, 48: 331-338.
128. Perussia,
B., Tutt, M.M., Qiu, W.Q., Kuziel, W.A., Tucker, P.W., Trinchieri, G., Bennett,
M., Ravetch, J.V., and Kumar, V. (1989). Murine Natural Killer Cells Express
Functional Fcγ Receptor II Encoded by the FcγRα Gene. J. Exp. Med., 170: 73-86.
129. Webb,
C. F., Tucker, P. W. and Dowton, S.B. (1989). Expression and Sequence Analyses
of Serum Amyloid A in the Syrian Hamster.
Biochemistry, 28: 4785-4790.
130. Word,
C.J., White, M.B., Kuziel, W.A., Shen, A.L., Blattner, F.R. and Tucker, P.W. (1989). The Human
Immunoglobulin Cμ-Cδ
Locus: Complete Nucleotide Sequence and Structural Analysis. International
Immunol., 1: 296-309.
131. Kuziel,
W.A., Word, C.J., Yuan, D., White, M.B., Mushinski, F., Blattner, F.R. and Tucker, P.W. (1989). The Human Immunoglobulin Cμ-Cδ Locus: Regulation of μ and δ RNA Expression During B Cell Development. International Immunol.,
1: 310-319.
132. Hedley, M.L., Ozato, K., Maryanski,
J., Tucker, P.W., and Forman, J. (1989). Expression of Mutant
H-2d Proteins Encoded by Class I Genes which Alternatively process the 5' End
of their Transcripts. J. Immunol., 143: 1026-1031.
133. Hedley, M.L., Forman, J. and Tucker, P.W.
(1989). Mutation of 3' Splice Sites in Two Different Class I
Genes Results in Different Usage of Cryptic Splice Sites. J.
Immunol., 143: 1018-1025.
134. Capra, J.D. and Tucker, P.W. (1989) Human
Immunoglobulin Heavy Chain Genes (Invited Review). J. Biol. Chem., 264: 12745-12748.
135. Johnson, D.G., Carayannopoulos, L.,
Capra, J.D., Hanke, J.H. and Tucker,
P.W. (1991). The Ubiquitous Octamer-Binding
Protein(s) is Sufficient for Transcription of Immunoglobulin Genes. Mol.
Cell. Biol., 10: 982-990.
136. Meek, K.,
Rathbun, G., Reininger, L., Jaton, J.-C, Kofler, R., Tucker, P.W. and Capra, J. D.
(1990). Organization of the Murine
Immunoglobulin VH Complex : Placement of Two New VH
Families (VH10) and (VH11) and Analysis of VH Family Clustering and Interdigitation. Mol. Immunol., 27: 1073-1081
137. Garni-Wagner, B.A., Witte, P.L., Tutt,
M.M., Kuziel, W.A., Tucker, P.W. and Kumar, V. (1990). Natural Killer Cells in the Thymus: Studies on Mice with Severe
Combined Immune Deficiency (scid). J. Immunol., 144: 796-803.
138. Sanz, I., Kelly, P., William, C., Scholl,
S., Tucker, P.W. and Capra, J.D.
(1989). The Smaller Human VH
Gene Families Display Remarkably Little Polymorphism. EMBO J., 8: 3741-3748.
139. Yoffe, G., Howard-Peebles, P.N., Smith, R.G., Tucker, P.W. and Buchanan, G.R. (1990). Childhood Chronic
Lymphocytic Leukemia with t(2;14) Translocation. J. Pediatrics, 116: 114-117.
140. Cerny, J., Smith, J.S., Streibich,
C.C., Webb, C.F. and Tucker, P.W.
(1991). Properties of Anti-idiotypic T
Cell Lines Propagated with Syngeneic B Lymphocytes. II. Proliferative Responses
of T Cells to The Idiotype-bearing B Cells. J.
Immunol., 147: 4351-4359.
141. White, M.B., Word, C.J., Humphries, C-G.,
Blattner, F.R.,and Tucker, P.W. (1991). Immunoglobulin D Switching Can Occur
Through Homologous Recombination in Human B Cells. Mol. Cell. Biol., 10: 3690-3699.
142. Carayannopoulos, L., Hanke, J. H.,
Johnson, D.G., Tucker,P.W., and Capra, J.D. (1990). Purification and Partial Characterization of 70 kD and 92 kD Proteins
Associated with OTF-1. J. Protein Chem., 51: 347-359
143. Webb, C.F., Das, C., Calame, K. and Tucker,
P.W. (1992).Involvement of Matrix Associated Regions in B Cell Specific
Protein-DNA Interactions Required For Antigen + IL-5 Induced Immunoglobulin
Transcription. Mol. Cell Biol., 11:
5197-5205.
144. Willard, M., Berton, M.T., and Tucker, P.W.
(1992). Coexpression of μ and γ1 Heavy Chains can Occur by a
Discontinuous Transcription Mechanism form the same Unrearranged Chromosome. Proc. Natl. Acad. Sci. USA. 89: 1234-1238.
145. Koop, B.F., Richards, J.E., Durfee, T.D.,
Bansberg, J., Wells, J., Gilliam, A.C., Chen, H.-L., Clausell, A., Tucker,
P.W., Blattner, F.R. (1996). Analysis and Comparison of the Mouse and Human
Immunoglobulin Heavy Chain JH-Cμ-Cδ Locus. Molecular Phylogenetics & Evolution, 5: 33-49.
146. Kienker, L.J., Kuziel, W.A.,
Garni-Wagner, B.A., Kumar, V. and Tucker, P.W. (1991). T Cell Receptor γ and δ Gene Junctional Sequences in Scid
Mice: Excessive P Nucleotide Insertion.
J. Exp. Med., 174:
769-773.
147. Moore, B. B., Tan, J., Leong, P.-L.,
Tucker, P. W. and Yuan, D.C. (1993). Regulatory Elements Necessary for
Termination of Transcription within the IgH chain locus, Nucleic Acids Res., 21:
1481-1488.
148. Berman, J. E., Humphries, C. G.,
Barth, J., Alt, F. W. and Tucker, P.W. (1992). Structure and Expression of
Human Germline VH Transcripts.
J. Exp. Med., 173: 1529-1535.
149. Kuziel, W.A., Lewis, J., Nixon-Fulton, J.,
Tigelaar, R.E. and Tucker, P.W. (1991). Murine Epidermal γ/δ T Cells Express Fcγ Receptor II
Encoded by the FcγRα Gene. Eur. J. Immunol., 21: 1563-1566.
150. Webb, C.F., Das, C., Eneff, K.L., and Tucker, P.W. (1992). Immunoglobulin 5' Flanking Region That Binds
to Antigen + IL-5 Inducible Proteins Also Binds to the Nuclear
Matrix. Mol. Cell. Biol., 11: 5206-5211.
151. Ariizumi, K. Ghosh, M. R, and
Tucker, P.W. (1993). Elements within
The Immunoglobulin Heavy Chain Enhancer Directly Regulate SV40 Ori-Dependent
DNA Replication. Mol. Cell. Biol., 13: 5629-5636.
152. Richardson, A. L., Humphries, C. G.
and Tucker, P.W. (1992). Molecular Cloning and Characterization of the t(2;14)
Translocation Associated with Childhood Chronic Lymphocytic Leukemia. Oncogene, 7: 961-970.
153. Ariizumi, K. Wang, Z., and Tucker,
P.W. (1993). Immunoglobulin Heavy Chain Enhancer is Located near or in the
Initiation zone of Chromosomal DNA Replication. Proc. Natl. Acad. Sci. USA,
90: 3695-3699.
154. Parikh, V.S., Nakai, C., Yokota, S.J.,
Bankert, D. and Tucker, P.W. (1992). COOH Terminus of Membrane IgM Is Essential
for an Antigen-specific Induction of Some But Not All Early Activation Events
in Mature B Cells. J. Exp. Med., 174:
1103-1109.
155. Kienker, L.J., Kuziel, W.A.,
Garri-Wagner, B.A., Kumar, V., and Tucker, P.W. (1991). T Cell Receptor γ and δ Gene Rearrangements in Scid
Thymocytes: Similarity to Those in Normal Thymocytes, J. Immunol. 147: 4351-4359.
156. Sawyer, J.R., Tucker, P.W. and Blattner,
F.R. (1992). Metal Binding Chimeric
Antibodies Expressed in E coli. Proc. Natl. Acad. Sci. USA., 89: 9754-9758.
157. Das, C., Kulkarni, P.V., Constantinescu,
A., Blattner, F.R. and Tucker, P.W. (1992).
Recombinant Antibody-Metallothionein: Design and Evaluation for
Radioimmunoimaging. Proc. Natl. Acad.
Sci. USA., 89: 9749-9753.
158. Parikh, V.S., Bishop, G.A., Liu, K.-J., Do,
T., Ghosh, M., Kim, B.G. and Tucker, P.W. (1993). Differential Structure-function Requirements of the
Transmembranal Domain of the B Cell Antigen Receptor. J. Exp. Med. 176: 1025-1031.
159. Cai, J., Humphries, C., Lutz, C. and
Tucker, P.W. (1993). Analysis of VH251
Gene Mutation in CLL and Normal B Cell Subsets. Annals. N.Y. Acad. Sci. 651:
384-393.
160. Cai, J., Humphries, C., Richardson, A. and
Tucker, P.W. (1993). Extensive and
Selective Mutation of A Rearranged VH5 Gene in Human B Cell Chronic
Lymphocytic Leukemia. J. Exp. Med. 176: 1073-1081.
161. Li, C. and Tucker, P.W. (1993). Exoquence DNA Sequencing. Nuc.
Acids Res., 21: 1239-1244.
162. Yang, Y.-S., Hanke, J.H., Carayannopulos,
L., Craft, C.M., Capra, J.D., and Tucker, P.W., (1993). NonO: A Non-POU Domain-Containing;
IgH Octamer Binding Protein Is the Mammalian Homologue of Drosophila
nonA. Cell Mol. Biol., 13: 5593-5603.
163. Cooper, C., Johnson, D., Roman, C.,
Avitahl, N., Tucker, P.W., and Calame, K. (1993). The C/EBP Family of Transcriptional Activations is Functionally
Important for Immunoglobulin VH Promoter Activity in vivo and
in vitro. J. Immunol. 149: 3225-3231.
164. Moore, B.B., Ariizumi, K., Tucker, P.W.,
and Yuan, D. (1993). Transcriptional Analysis of Inhibition of LPS Response by
Anti-IgM. J. Immunol., 150: 3366-3374.
165. Ishihane, K., Wood, W.J., Wall, R.,
Michnoff, C., Tucker, P.W. and Kincade, P.W. (1992) Multiple B29 Containing
Complexes on Murine B lymphocytes. Common and Stage Restricted Ig-Associated
Polypeptide Chains. J. Immunol., 150:
2253-2262.
166. Tucker, P.W. (1992) Immunoglobulin D. In
Human Protein Data (A. Haeberli, ed.) VCH Verlagsges, pp202-204.
167. Tuaillon, N., Taylor, L.D., Lonberg,
N., Tucker, P.W., and Capra, J.D. (1993). Human Immunoglobulin Heavy Chain
Minilocus Recombination in Transgenic Mice: Gene-Segment Use in μ and γ Transcripts. Proc. Natl. Acad. Sci. USA, 90: 3720-3724.
168. Yang, Y.-S., Watson, W., Capra, J.D., and
Tucker, P.W. (1993). Construction of
Recombinant DNA By Exonuclease Recession. Nuc.
Acids. Res., 21: 1889-1893.
169. Tuaillon, N., Miller. A.B., Lonberg,
N., Tucker, P.W. and Capra, J.D. (1994).
Biased Utilization of DHQ52 and JH4 Gene Segments
in a Human Immunoglobulin Transgenic Minilocus is Independent of Antigenic
Selection. J. Immunol., 152:
2912-2920.
170. Li, C. and Tucker, P.W. (1993). DNA-binding properties and secondary
structural model of the hepatocyte nuclear factor 3/fork head domain. Proc.
Natl. Acad. Sci. USA, 90: 11583-11587.
171. Clausell, A. and Tucker, P.W.
(1994). Functional analysis of the Vγ3 Promoter of the Murine γδ T Cell
Receptor. Mol. Cell. Biol., 14:
803-814.
172. Kuziel, W.A., Kienker, L.J. and Tucker,
P.W. (1993). Physical Linkage of mouse
T cell receptor V genes: I. Evolutionary and regulatory features of the Vγ1.1-Vγ1.2 intergenic region. Immunogenetics, 39: 298-299.
173. Kienker, L.J. and Tucker, P.W.
(1993). Physical linkage of mouse T
cell receptor V genes: II. Regulatory features of the Vγ4-Vγ3 intergenic region. Immunogenetics,
39: 298-299.
174. Kienker, L.J., Ghosh, M.R. and
Tucker, P.W. (1998). Regulatory
Elements in the Promoter of a Murine TCRD
V Gene Segment. J.
Immunol., 161: 791-804.
175. Liu, K.-J., Parikh, V. S., Tucker, P.W. and
Kim, B.S. (1993). Role of the B Cell
Antigen Receptor in Antigen Processing and
Presentation. J. Immunol., 151: 6143-6154.
176. Michnoff,
C.H., Parikh, V.S., Lelsz, D.L. and Tucker, P.W. (1995). Mutations in membrane immunogloblin M
transmembranal domain alter signal transduction and association with Igα and Igβ. J. Biol. Chem., 269: 24237-24244.
177. Webb, C.F., Eneff,
K.L., Drake, F.H. and Tucker, P.W. (1993). A topoisomerase II-like protein is
part of an inducible DNA-binding protein complex that binds 5¢
of an immunoglobulin promoter. Nuc.
Acids Res. 18:
4363-4368.
178. Ono, M. Tucker, P.W. and Capra, J.D.
(1994). Production and characterization
of recombinant Ku. Nuc. Acids Res., 22: 3918-3924.
179. Yang, Y.-S., Yang, M.-C., Watson, W.J.,
Tucker, P.W., and Capra, J.D.
(1995). Directional cloning of
an oligonucleotide fragment into a single restriction site. J. Immunol. Methods, 181: 137-140.
180. Liu, K.-J., Parikh, V.S., Tucker, P.W. and
Kim, B.-S. (1996). Surface
immunoglobulins mediate efficient transport of antigen to lysosomal compartments
resulting in enhanced specific antigen presentation by B cells. Eur.
J. Immunol., 24: 2755-2760.
181. Tuaillon, N., Miller, A.B., Lonberg,
N., Capra, J.D. and Tucker, P.W. (1995).
Analysis of direct and inverted DJH rearrangements in a human
Ig heavy chain transgenic minilocus. J.
Immunol., 154: 6453-6465.
182. Parikh, V.S., Oz, O.K., and Tucker, P.W.
(1996). Novel
metallothionein-conjugates for imaging and therapy of tumors. Tumor Targeting, 1: 285-287.
183. Kenny, J.J., Stall, A.M., Fischer, R.T.,
Wang, M.-C., Longo, D.L. and Tucker, P.W. (1996). Immunoglobulin γ2b transgenes
promote B cell development, but alternate developmental pathways appear to
function in different transgenic lines.
J. Immunol., 154: 5694-5705.
184. Herrscher, R.F., Kaplan, M.H.,
Lelsz, D.L., Das, C., Scheuermann, R. and Tucker, P.W (1996). Immunoglobulin
gene expression is regulated by Bright: A B cell specific, MAR-binding
transactivator that contains a new class of DNA binding domain. Genes and Development, 9: 3067-3082
185. Kenny, J.J., Claflin, J.L., Reed, J.,
Longo, D.L. and Tucker, P.W. (1994).
Analysis of antigen-driven positive and negative selection of
phosphocholine-specific bone marrow B cells.
Current Topics in Microbiology and
Immunology. 194: 235-244.
186. Crawford, H.C., Shin, E.-K., Moore,
B., Rivkin, E., Humphries, C-G., Nevins, J.R. and Tucker, P.W. (2001). A sequence between the poly(A) sites of the
Immunoglobulin μ heavy chain
gene contributes to developmentally regulated 3'-end usage by negating
transcriptional termination. Submitted
to Genes and Development.
187. Lelsz, D.L., Michnoff, C.H., and Tucker,
P.W. (2001). Conserved Tryptophan in
the Immunoglobulin M Transmembrane Domain Implicated in Signaling and Igα Association. Submitted.
188. Kortschak, R.D., Saint, R. and
Tucker, P.W. (2000). ARID Proteins Come in From Desert. TIBS, (invited review).TIBS 25: 294-299.
189. Sonoki, T., Matsuzaki, H., Satterwhite, E., Nakzzawa, N., Hata, H., and Tucker, P.W. (1999). Plasma Cell Leukemia patients Showing Biallelic 14 Translocations: t(2;14) and t(11;14). Acta Haematol. 101: 197-201.
190. Kluin, P.M., Kayano, H., Zani, V.J.,
Kluin-Nelemans, H.C., Tucker, P.W., Satterwhite, E., Dyer, M.J. (1997). IgD
Class Switching: Identification of Novel Recombination Site in Neoplastic and
Normal B Cells. European J. Immunol. 25:
3504-3508.
191. Tuaillon, N., Capra, J.D. and
Tucker, P.W. (1996). VHDJH
Recombination in a Human Immunoglobulin Heavy Chain Transgenic Minilocus. The
Immunologist, 3: 5-10.
193. Ono, M., Capra, J.D. and Tucker, P.W.
(1997). Ku is a general inhibitor for
DNA-protein complex formation and transcription. Mol. Immunol., 33: 787-796.
194. Kaplan, M.H., Zong, R.-T., Herrscher, R.F., Scheruermann, R.H., and Tucker, P.W. (2001). Transcriptional Activation by a Matrix Associating Region-binding Protein: Contextual Requirements for the Function of Bright. J. Biol. Chem.276: 21325-21330.
195. Yang, Y.-S., Yang, M.-C., Capra, J.D. and
Tucker, P.W. (1997). NonO Enhances the
Association of Many DNA-binding Proteins to Their Targets. Nuc.
Acid. Res., 25: 2284-2292.
196. Wang, Z., Goldstein, A., Zong, R.-T., Lin,
D., Neufeld, E.J., Scheruermann, R. H., and Tucker, P.W. (1999). Cux/CDP Homeoprotein is a Component of NF-mNR and Represses the Immunoglobulin Heavy
Chain Intronic Enhancer by Antagonizing the Bright Transcription
Activator. Mol. Cell. Biol., 19:
284-295.
197. Kenny, J.J., Derby, E.G., Yoder, J.A.,
Hill, S.A., Fischer, R.T., Tucker, P.W., Claflin, J.L., and Longo, D.L. (1998).
Positive and Negative Selection of
Antigen-Specific B Cells inTransgenic Mice Expressing Variant Forms of the VH1
(T15) Heavy Chain. International Immunol.
12: 873-8.
198.
Liu, K.-J.,
Schwen, M., Tucker, P.W., and Kim, B.S. (1998). Hybrid Membrane IgM with the
Transmembrane Region of I-Aa Facilitates
Enhanced Presentation of Distinct Epitopes to T Cells. J.
Immunol., 160: 4161-4168.
199.
Zong, R-T., Das, C., and Tucker, P.W. (2000). Regulation of
MAR-Dependent, Lymphocyte-Restricted Transcription Through Differential
Localization within PML Nuclear Bodies.
EMBO J. 19: 1-11.1
200.
Karhumaa, P., Parkkila, S., Waheed, A., Parkkila, A.-K.,
Kaunisto, K., Huang, C.-J., Sly, W.S., Tucker, P.W., and Rajaniemi, H. (2000).
Nuclear NonO/p54nrb Is a Nonclassical Carbonic Anhydrase. J. Biol. Chem. 275: 16044-16049.
201.
Webb, C., Zong, R.-T., Lin, D., Wang, Z., Kaplan, M.,
Paulin, Y., Smith, E., Probst, L., Bryant, J., Goldstein, A., Scheuermann, R.,
and Tucker, P.W. (2000). Differential Regulation of Immunoglobulin Gene Transcription via Nuclear Matrix-associated
Regions. Cold Spring Harbor Symps. Quant.
Biol. 64: 109-118.
202. Satterwhite, E., Sonoke, T., Willis, T.G., Siebert, R., Nowak, R., Arriola, E.L., Liu, H., Harder, L., Price, H.P., Gesk, S., Steinmann, D., Oscier, D.G., Schlegelberger, B., Dyer, M.J.S., and Tucker, P.W. (2001). The BCL11 gene family: Involvement of BCL11A in lymphoid malignancies. Blood, in press.
203.
Lin, D., Wang, Z., Scheuermann, R.H., and Tucker, P.W.
(2001) hnRNP-A1/B1 is a component of NF-μNR that abrogates Cux/CDP
mediated repression of the immunoglobulin heavy chain intronic enhancer via
interaction with its matrix associated regions. J. Immunol., in revision.
204. Sinclair, A.M., Lee, J., Goldstein, A., Xing, D., Lu, N., Ju, R., Levaseur, K.E., Neufeld, E.J., Tucker, P.W., and Scheuermann, R.H. (2001) CCAAT displacement protein (CDP/Cux) regulates normal lymphoid and myeloid development in part by modulating TNF expression. Blood, in press.
206. Wang, B., Li, C., and Tucker, P. W. (2002) A B cell-restricted, polygutamine-containing forkhead transcriptional repressor, QRF-1. J. Biol. Chem., in press.
207. Zhang, Y., Li, C., and Tucker, P.W. (2002) PTIP/QRF-2, a novel BRCT-domain containing apoptosis factor that directly promotes cytochrome C release from mitochondria to cytoplasm. In preparation.
208. Zong, R.-T., Das, C., Probst, L., and
Tucker, P.W. (2001) Modulation of the B cell-specific transcription factor
Bright by interaction with the ubiquitin-conjugating enzyme UBC9 and
modification by SUMO. J Immunol. in revision.
209. Huang, C.-J., Lin, R.J., and Tucker, P.W.
(2002) SR phosphorylation regulates the
binding of PSF to the pre-mRNA intronic polypyrimidine tract. Submitted to RNA.
210 Mathur, M., Tucker, P.W., and Samuels, H.
(2001) PSF is a novel co-repressor that mediates its effect through Sin3A and
the DNA binding domain of nuclear hormone receptors. Mol.
Cell. Biol 21:
2298-2311.
211. Cai, J. and Tucker, P.W. (2001). gd
T cells: Immunoregulatory functions
and
imunoprotection (invited review)
Chemical Immunology,
in press.
212. Sewer, M.B., Nguyen, V., Xie, W., Tucker, P.W., and Waterman, M.R. (2002) p54nrb/NonO is an SF-1 binding partner required for the cAMP-dependent transcriptional activation of human CYP17. Endocrinology, in press.
213. Martin-Subero,
J.I., Gesk, S., Sonoki, T., Hansmann, M.L., Dyer, M.J.S., Tucker, P.W., and
Siebert, R. (2002) Recurrent involvement of the Rel and BCL11A loci in
classical Hodgkin’s Lymphoma. Blood, in
press.
214. Kuppers, R., Sonoki, T.,
Satterwhite, E., Gesk, S., Harder, L., Oscier, D.G., Dyer, M.J.S., Siebert, R.,
and Tucker, P.W. (2002) Lack of somatic hypermutation of IgH genes in lymphoid
malignancies with t(2;14)(p13;q32) translocations involving the BCL11A
gene. Submitted to Blood.