The thymus is critical for the T cell maturation
Whn, transcription factor required for terminal epithelial differentiation, is defectè no thymusè nu/nu only with B cells
B and T cells fail to develop because of a defect in VDJ rearrangement (DNA-PK)
Bone marrow precursors from nu/nu develop normally
Thymic epithelial cell from scid can induce the T cell maturation
Tissue Graft Experiment