Ig Rearrangements and Cell Surface Markers
• Intermediate stages can be distinguished by other cell-surface proteins and DNA analysis of immunoglobulin loci rearrangement
•
•Pre-B receptor expression requires accessory chains Igα and Igβ
Kit:
receptor for SCF. Stimulates both lymphoid and myeloid development in the bone
marrow
IL7
receptor:
essential for the growth and survival of developing B (in mice) and T cells (mice and humans)
ceases at the later pro-B
Turns on after Kit