•Btk: Bruton’s tyrosine
kinase. Mutation causes a profound B-lineage specific immune
deficiency (Bruton’s X-linked agammaglobulinemia, XLA) in
which no mature B-cells are produced.
•Mouse equivalent (xid) more “leaky”; some mature
B cells get by pre-B block, but they are signaling
compromised as well.
•Tec family tryrosine kinase
regulated via PKC, Ca2+ pathway (Chapter 6);
•Mutations in plextrin
homology domain (PHD)