• If both H chain rearrangements are
nonproductiveè no pre-B cell receptor è death
•In pre-B cells with a successful
VDJ rearrangement, pre-B cell receptor can receive signal to halt rearrangement and
to start proliferation
D to JH VH to DJH
VL to JL
3 stages to make functional receptor
The steps in
immunoglobulin gene rearrangement at which cells can be lost