Proteins binding to promoter and enhancer contribute to the sequence of gene rearrangement and regulate the level of RNA transcription
B cell heavy chain
Intronic and 3’ (to Cα) enhancers (e)
Transcription factors bind to the DNA and OPEN the chromatin, making it accessible to the recombinase enzymes
Chromatin modulation by histone modifications; nucleosome phasing. “germline/sterile” transcripts initiated from cryptic Ps.
Oct2, Bright/Arid3a, Pax5 can bind and transactivate through both e and Ps.
Rate of transcriptional initiation increased and maintained.
 Role of accessibility and transcription in somatic hypermutation and class switch recombination