Intronic and 3’ (to Cα) enhancers (e)
Transcription factors bind to
the DNA and OPEN the chromatin, making it accessible to the recombinase enzymes
Chromatin modulation by histone modifications; nucleosome
phasing.
“germline/sterile” transcripts initiated from cryptic Ps.
Oct2, Bright/Arid3a, Pax5 can
bind and transactivate
through both e and Ps.
Rate of transcriptional
initiation increased and maintained.
Role of accessibility and transcription in somatic hypermutation and class
switch recombination