-Rearrangement of only one allele at a time
-repeated rearrangements of
unused V and
J segments of each allele
-The chances for generating an intact light chain are increased
-Isotypic exclusion: the production of a light chain from only one of the
two light chain
loci, κ or λ
-κ vs λ-expression: varies in different speciesè correlates with numbers of V κ or Vλ gene segments.
Ex. Rats= 95:5 ; cats= 5:95
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