TdT: Throughout the developmental
period
Cytoplasmic protein tyrosine
kinase Lck (if deficient: T cell is arrested
before double positive stage and no α chain)
ZAP70: promote single positive
thymocytes from
double positive ones
Transcription factors: guide
development and
often have roles in mature T cells
Inappropriate expression of Notch-lymphomas;
RAG1 and 2 are repressed once pre-T cell receptor is presentè
proliferate è α rearrangement
begins. This ensures β is successfully
rearranged and gives rise many double
positive cells with different α
The temporal
pattern of relevant cellular proteins in T-cell
development