The stages of T
cell development are marked by changes in cell-surface
molecules
Progenitor cells form bone marrow:
No T-specific surface molecules
Receptor genes are not rearranged
major
minor
~20% DN
~20%
DN NKT
(not
shown)
Interaction with thymic stroma trigger initial phaseè cell
proliferation and expression of first surface molecules (eg, Thy1/CD2)but not CD3,
CD4,
or CD8
Several proliferation cycles