Figure 6-4
New Binding Sites
• Phosphorylation can lead to formation of binding sites
• Allows concentration of susceptible proteins near protein kinases
• SH2 (Src homology 2 domain) is a domain that is found in Src kinases and many other proteins and binds phosphotyrosine
• SH3 (Src homology 3 domain) binds proline-rich regions in other proteins and allows recruitment of these proteins
•PH (Pleckstrin-Homology) domains interact with phosphorylated lipids on inner face of membranes (Tec kinases)