Adaptor
Molecules
• Link cell-type
specific signal transduction events to common response pathways (activation of PLC-γ, PKC,
etc…)
•Lymphocyte adaptor molecules have SH2 and SH3 domains,
lack kinase activity, act to
position correct molecules near the membrane surface and facilitate signal transduction (Eg: GEFs, LAT, SLP-76,
BLNK)