Localization
•Membranes – not uniform, but contain microdomains - Dynamic glycolipid enriched microdomain (GEM) or lipid raft
•Cholesterol rich, rigid, little branching, resistant to solubilization by detergents
•Proteins with lipid attachments (such as Src kinases) as opposed to hydrophobic transmembrane
domains prefer these regions -Preference developed for lipid rafts upon cross-linking BCR and TCR