•Zap70
•In T-cells, ZAP-70 does not perform
transphosphorylate itself
after ITAM binding.
•Instead, after it binds the ITAMs of the CD3 and ζ chains, it is phosphorylated and activated by the Lck associated with the co-receptors CD4 and CD8.
•Zap70 propages signal inwards by phosphorylating LAT and SLP-76
•LAT is in lipid rafts; contains many tyrosines.
Both Syk and ZAP-70 then propagate the signal inwards.
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