Common
players in signal propagation
PLC-γ
•A key enzyme in phosphatidylinositol bisphosphate (PIP2) metabolism and lipid signaling pathways; activated by pTyr and membrane
recruitment.
•Contains two SH2 domains and one SH3 domain (required
for recruitment
• Cleaves membrane
lipid PIP2; one molecule can
cleave many PIP2 amplifying
and sustaining the signal