New
Binding Sites
• Phosphorylation
can lead to formation of binding sites
• Allows
concentration of susceptible proteins near protein kinases
• SH2 (Src homology
2 domain) is a domain that is found in Src kinases and many other proteins and binds phosphotyrosine
• SH3 (Src homology
3 domain) binds proline-rich regions in other proteins and allows recruitment of these proteins
•PH (Pleckstrin-Homology) domains interact with
phosphorylated lipids on inner
face of membranes (Tec kinases)