Part I. Overview of basic strategies of molecular signaling
• Signal transduction, the basic problem addressed:
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•How to convert external receptor binding event -> across membrane -> into intracellular biochemical event
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•Common Properties: signal amplification, multiple levels with controls at each level
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•For lasting changes the ultimate destination is the nucleus and regulation of transcription
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•Results of signal transduction: changes in cytoskeleton, rearrangement of secretory apparatus, progression of the cell cycle, etc…