Figure 6-6
Adaptor Molecules
• Link cell-type specific signal transduction events to common response pathways (activation of PLC-γ, PKC, etc…)
•Lymphocyte adaptor molecules have SH2 and SH3 domains, lack kinase activity, act to position correct molecules near the membrane surface and facilitate signal transduction (Eg: GEFs, LAT, SLP-76, BLNK)